Surprising Antiviral Effects of Coffee Demonstrated in New Study and Clinical Trial


In an exciting revelation for coffee lovers, an intriguing study, newly published in Cell and Bioscience journal, has found that your daily cup of joe might offer more than just a caffeine kick. This research delves into coffee's potential role in inhibiting SARS-CoV-2, the virus responsible for the COVID-19 pandemic.

Coffee, a global morning staple, is packed with polyphenols like caffeic and chlorogenic acids, alongside antioxidants such as trigonelline and cafestol. A notable study among UK Biobank participants linked regular coffee consumption (at least one cup daily) to a reduced risk of contracting COVID-19. But the mechanics behind this protective effect remained a mystery, until now.

Discovering Coffee's Antiviral Secrets

In this latest study, scientists from Taiwan examined the effects of coffee on the replication rate of SARS-CoV-2 in human cell lines. Remarkably, both ground and instant coffee varieties demonstrated a dose-dependent suppression of viral entry. Even common coffee additives like cream and sugar didn't diminish this effect.

Further investigations revealed that compounds found in coffee can disrupt the interactions between the virus's spike protein and the ACE2 receptor, a crucial entry point for the virus into human cells. Additionally, coffee was found to inhibit the activity of TMPRSS2, an enzyme that facilitates viral entry, and cathepsin L, another key player in the virus's invasion process.

The Potent Compounds in Coffee

Digging deeper, researchers used advanced chromatographic techniques to pinpoint the specific compounds in coffee responsible for these effects.

They identified two fractions containing a mix of compounds like CGA, caffeine, luteolin, and isochlorogenic acids (isoCGAs) that were particularly effective against the virus. Among these, isoCGA-A emerged as the most potent inhibitor.

Human Trials: Validating Coffee's Protective Role

The same study further conducted a human trial involving 64 healthy Taiwanese participants who were randomized to the control group (water), low-dose regular coffee (4 mg, about 1 cup/ 240 ml), high-dose regular coffee (8 mg, ~2 cups), and high-dose decaffeinated coffee (8 mg, ~2 cups). The scientists then collect their serum samples to be tested for any antiviral activities against SARS-CoV-2.

Results showed that serum samples derived from those in the regular or decaffeinated coffee consumption groups led to a noticeable inhibition of the virus, including variants like Omicron. This suggests that it's not just caffeine but other bioactive compounds in coffee that confer this anti-SARS-CoV-2 protection.

The study concludes that regular coffee consumption might be a viable dietary strategy to fortify ourselves against SARS-CoV-2 infection. As we move forward in the post-COVID era, embracing our daily coffee ritual could be more than just a lifestyle choice; it might be a proactive step towards safeguarding our health.

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