A recent study found evidence why women are more at risk from Alzheimer's than men

Living Smart

While the accumulation of brain proteins is a sign of the onset of Alzheimer's disease, a new study analyzes the ways in which these proteins spread, which may help explain why the disease occurs. more common in women than in men. A recent study presented at an international Alzheimers Association conference identified differences in the prevalence of a protein called tau, which is associated with cognitive impairment, between men and women, with women showing greater accumulation of tau throughout the brain than fast-spreading men through the brain.

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brain scanningShutterstock

The accumulated evidence suggests that tau spreads through brain tissue as an infection, travels from neuron to neuron, and makes other egg proteins abnormal tangles that in turn kill brain cells. The researchers used data from positron emission tomography (PET) scans of healthy individuals and patients with mild cognitive impairment entered into the Alzheimer's Disease Neuroimaging Initiative (ADNI) database.

"It's a bit like building a crime scene after a crime. You weren't there when it happened, but you can tell where the robber entered the house and what room he came to," Sepi said. Shokouhi, principal investigator at the study.

"The analysis of the graph is a bit like showing how the rope spreads from one area to another," Shokouhi added.

The findings show that the architecture of tau networks differs between men and women, with many women having multiple "connecting areas" connecting different brain communities. This difference could allow tau to spread more rapidly between regions, increase its rate of accumulation and expose women to a greater risk of developing Alzheimer's disease. The study's lead researcher said, "Understanding how different biological processes affect our memory is an important topic."

"Gender-specific differences in brain pathology, neuroanatomy, and functional organization can be mapped to differences at the neuro-behavioral and cognitive levels, which explains the differences in the prevalence of neurodegenerative diseases and helps us to develop appropriate treatments," Shokouhi said. Source article.

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