Researchers found higher thyroid hormone levels associated with artery disease and early death

Living Smart

Researchers analyzed data from 9,420 members (average age 65, fifty-seven percentage women) in the Rotterdam Study searching at facts on two sorts of hormones: thyroid-stimulating hormone and free thyroxine (known as FT4) and their hyperlink to atherosclerosis and demise due to coronary heart disease, cerebrovascular disorder or other artery-related illness.

FT4 is a hormone produced by way of the thyroid gland that helps manage the charge at which the body makes use of energy. Atherosclerosis is the system of revolutionary thickening and hardening of the walls of arteries from fat deposits on their inner lining. Researchers decided on asymptomatic atherosclerosis by measuring coronary artery calcification.

After a median follow-up of 8.8 years, the researchers observed 612 cardiovascular deaths related to atherosclerosis and 934 first cardiovascular events related to atherosclerosis. Increased FT4 levels are associated with:

  • a double chance of having high levels of coronary artery calcification - which may be a sign of subclinical atherosclerosis;
  • an 87 percent higher risk of suffering from a cardiovascular event associated with atherosclerosis; en
  • twice the risk of cardiovascular death associated with atherosclerosis.

"We expect thyroid function to affect the risk of developing atherosclerosis by influencing cardiovascular risk factors such as blood pressure. However, our results remain very similar after calculating various cardiovascular risk factors," said study lead author Arjola Bano, MD, M.Sc

Researcher in internal medicine and epidemiology at Erasmus University in Rotterdam, the Netherlands. "This suggests that mechanisms other than traditional cardiovascular risk factors may play a role. "Our findings suggest that measuring thyroid hormone FT4 may help identify individuals at increased risk for atherosclerosis."

This study is considered to be the first population-based study to examine the relationship of thyroid function to atherosclerosis from subclinical atherosclerosis to overt disease and death.

The authors noted that the study did not measure thyroid hormone levels over time and included predominantly white middle-aged adults, so results would not be common in other populations.

"Clever studies should explain the exact mechanisms that can explain the link between thyroid function and atherosclerosis. This will help identify potential targets for future prevention strategies," he said. Source, source.

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