One of the most famous giants mentioned in the Bible is Goliath. Goliath was a Philistine giant described in the Book of Samuel in the Bible.
In the Bible, the giant Goliath confronted David. Goliath was killed when David threw a stone at his forehead.
As a giant, Goliath's height was reported to be "six cubits and a span." His family including his brother and sons were all giants.
An interesting article from the Ulster Medical Journal accounts for Goliath's gigantism by indicating that it might have been hereditary in nature.
The article states that Goliath's family tree was inflicted with a hereditary autosomal dominant pituitary gene. Thus, Goliath would have suffered from a pituitary gland dysfunction.
This dysfunction would have been his undoing as he would not have had the speed and agility to avoid the stone that David threw at his forehead. Although Goliath might have looked big and strong, his appearance was deceiving.
Not all scholars and historians believe that the giant Goliath existed as evidence is scant in that regard. However, there is a strong case that Goliath did fight against someone like David and was killed.
The argument in favor of Goliath's existence was that he was a member of an ancient Bronze Age society. Bronze Age societies commonly used single combat warriors as proxies to determine the outcome of a war. Hence, it made sense that Goliath and David were the warriors that represented each of their camps.
Archaeologists also note that the biblical description of Goliath's armor is consistent with the archaeological discoveries made in this era.